Three babies died of whooping cough in October amid the biggest outbreak in 20 years, health officials have said.
The total number of babies under the age of three months who have died as a result of the infectious disease this year now stands at 13, the Health Protection Agency (HPA) said.
The number of confirmed cases in England and Wales this year is now 7,728.
The HPA said 1,614 cases of whooping cough were reported in England and Wales in October. In 2011, the total number of cases was 819.
Health officials say all pregnant women are to be vaccinatedIn a move to combat the outbreak, health officials recently announced that all pregnant women are to be vaccinated against the infection.
Chief Medical Officer Professor Dame Sally Davies, the Government's principal medical adviser, said mothers-to-be will be offered the vaccination to protect their newborn babies.
Youngsters cannot receive the jab until they are two months old. Vaccinating their mothers before they are born will boost their immunity until they reach the age when they can have the injection themselves, she said.
Women across the UK who are between 28 and 38 weeks pregnant are being offered the vaccination.
Increases in whooping cough are usually seen every three to four years. The last rise in the number of confirmed cases was recorded in 2008.
Dr Gayatri Amirthalingam, consultant epidemiologist for immunisation at the HPA, said: "We strongly recommend all pregnant women take up the offer of vaccination."
In the very young, whooping cough can be a serious illness and can lead to death in some cases.
Babies and children can often make a distressing "whoop" sound while gasping for air after a coughing fit.
Professor David Salisbury, director of immunisation at the Department of Health, said: "Whooping cough is highly contagious and infants are particularly vulnerable.
"Thirteen infants have died as a result of whooping cough this year and there have been nearly 400 cases of the disease in children under three months old."
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