Four people are missing and two men have been taken to hospital after a house fire in east London, emergency services have said.
Fire crews tackled the blaze on Romford Road in Forest Gate in the early hours of Saturday morning.
The roof was destroyed in the fire and a large part of the ground and first floors of the property were damaged.
The building is believed to have been disused.
Firefighters rescued a man from the roof of the building and another man escaped before the fire brigade arrived.
Both men were taken to hospital by the London Ambulance Service.
Fire station manager Daniel Alie, who was at the scene, said: "The fire caused severe damage to the house and the roof was destroyed.
"Crews rescued a man from the rear of the house using a ladder. Both men have been taken to hospital to be treated for smoke inhalation.
"Our fire investigation unit is now working to find out what caused the blaze."
Eight fire engines from Leytonstone, East Ham, Plaistow, Stratford, and Bow fire stations attended the call, which was received at 3.09am.
There were around 60 firefighters and officers at the scene, and equipment included an aerial ladder platform and fire rescue unit.
The cause of the fire is under investigation.
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